| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 594637 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2011 | 7 Pages |
The efficacy and safety of chemotherapy is conditioned by the very high drug doses needed to obtain an efficient therapeutic activity, the poor pharmacokinetics of anticancer drugs, and the frequent multi-drug resistance of cancer cells. The application of nanotechnology strategies in oncology has revolutionized the transport of drugs to cancer, allowing the appearance of new treatments with an improved specificity. In order to enhance the antitumor activity of ftorafur along with an overcome of its important limitations, we investigated the development of a magnetically responsive nanoformulation with very appropriate drug delivery properties. The formulation of the ftorafur-loaded iron oxide/chitosan (core/shell) nanocomposite was based on a coacervation method. The main factors determining the vehiculization of the chemotherapy agent were analyzed. Compared to surface adsorption onto the preformed magnetic nanoparticles, ftorafur entrapment into the polymeric shell resulted in a much better drug loading and in a slower (prolonged) ftorafur release profile. Such stimuli-sensitive nanoformulation hold very important properties (e.g., magnetic targeting capabilities, blood compatibility, high drug loading, and little burst release) for an efficient delivery of ftorafur to tumors.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► This is, to our knowledge, the first time that ftorafur-loaded magnetite/chitosan (core/shell) nanocomposites are formulated. ► The article stresses the applicability of the magnetic nanoformulation for the treatment of cancer. ► The procedures used to obtain the magnetic nanoformulation and to load it with the chemotherapy agent are very carefully described. ► The role of surface adsorption, and its evaluation with electrophoretic mobility data is also a very original view of the problem. ► The release kinetics of the drug from this nanocarrier is also investigated.
