| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 594700 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2011 | 5 Pages |
Colloidosomes with porous shells have attracted attention in recent years because of the great potential as vehicles for controlled delivery of active ingredients. We present herein a simple and flexible method to prepare colloidosomes by a combination of particle-stabilized emulsion and solvent extraction method. We first generate an oil-in-water (o/w) emulsion where the dispersed phase is slightly soluble in the continuous phase and contains a water-insoluble polymer. Polystyrene particles, suspended in the dispersed phase, absorb onto the surface of oil droplet to stabilize the emulsions. The particles at the interface eventually become the shell of colloidosome microcapsules upon the removal of the oil by solvent-mediated diffusion. In addition, during the oil removal, the dissolved water-insoluble polymer likely deposits at the interface and binds the assembled polystyrene particles together, in turn leading to mechanical stable colloidosomes. We demonstrate that the size and morphology of the resultant colloidosome microcapsules depend on the type of the solvent and the oil extraction rate.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Colloidosome microcapsules comprising particles and polymers as the shell can be prepared by combining the Pickering emulsion template and solvent-mediated diffusion method. ► A general method to generate colloidosome microcapsules in a high yield at room temperature without the need of centrifugation or washing. ► The size and morphology of the resultant colloidosome microcapsules can be controlled by the rate of the oil extraction.
