Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5981955 | Journal of the American College of Cardiology | 2015 | 10 Pages |
Abstract
This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of randomization, appropriate use of blinding, and determination of trial size. Insights are made with reference to contemporary major trials in cardiology.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Stuart J. PhD, Tim C. MSc, Gregg W. MD,