Article ID Journal Published Year Pages File Type
5981955 Journal of the American College of Cardiology 2015 10 Pages PDF
Abstract

This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of randomization, appropriate use of blinding, and determination of trial size. Insights are made with reference to contemporary major trials in cardiology.

Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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