Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5982217 | Journal of the American College of Cardiology | 2015 | 13 Pages |
Abstract
As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the value of factorial designs, the importance and challenges of strategy trials, Data Monitoring Committees (including when to stop a trial early), and the role of adaptive designs. All topics are illustrated by relevant examples from cardiology trials.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Stuart J. PhD, Tim C. MSc, Gregg W. MD,