Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5984039 | Journal of Cardiology | 2015 | 5 Pages |
BackgroundCardiac troponin is widely accepted as a biomarker of myocyte injury in patients with myocardial ischemia. Patients with congestive heart failure are also associated with elevated cardiac troponin and it is a very sensitive prognostic marker. However, the mechanisms of troponin elevation in patients with heart failure are not fully understood. Decompensated state itself is suggested as a factor contributing to elevated cardiac troponin-T. However comparison between invasive hemodynamic parameters and cardiac troponin-T is insufficient.MethodsData were collected from 167 patients in stable, chronic HF, without acute coronary syndrome, recent revascularization, mitral stenoses, hemodialysis, or clinically significant right HF. We evaluated the correlations and 95% confidence intervals (CI) between invasive hemodynamic measurements and serum high-sensitivity (hs) concentrations of cTnT.ResultsThe serum cTnT concentration was equal to or more than the detection threshold (0.003 ng/ml) in all patients. The serum cTnT concentration was equal to or more than the cut-off value of 0.014 ng/ml in 46% of patients. By multiple variable analysis, left ventricular (LV) end-diastolic pressure (EDP; adjusted coefficient = 0.014; 95% CI 0.0003-0.029; P = 0.046) was positively correlated, while hemoglobin (adjusted coefficient = â0.079; 95% CI â0.140 to â0.018; P = 0.012), estimated glomerular filtration rate (adjusted coefficient = â0.008; 95% CI â0.013 to â0.003; P = 0.004), and LV ejection fraction (EF; adjusted coefficient = â0.011; 95% CI â0.018 to â0.003; P = 0.004) were negatively correlated with hs-cTnT concentrations.ConclusionIn patients with stable chronic HF, LVEDP and LVEF correlate with the serum concentrations of hs-cTnT, independently of other correlates of elevated plasma concentrations of hs-cTnT.