| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6003660 | Trends in Cardiovascular Medicine | 2014 | 7 Pages |
Abstract
Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a “molecular orchestrator” of a myriad of signal transduction pathways in the heart.
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Authors
Nirmala Hariharan, Mark A. Sussman,