Family-based association study of interleukin 10 (IL10) and interleukin 10 receptor alpha (IL10RA) functional polymorphisms in schizophrenia in Polish population

•Association analysis of functional polymorphisms of IL10 and IL10RA in schizophrenia•Family-based study on 146 trios using transmission disequilibrium test•Lack of association for IL10: rs1800872, rs1800871, rs1800896, rs1800890, rs6676671•Lack of association with schizophrenia for IL10RA: rs3135932, rs2229113•Haplotype analysis-no association with schizophrenia in Polish population

Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. Interleukin-10 (IL10) and it's receptor IL10RA may play an important role for immunological aspects in etiologies of major psychiatric disorders including schizophrenia. The aim of this study was to perform a transmission disequilibrium test (TDT) on a group of 146 schizophrenia trios from the Polish population. Functional polymorphisms from IL10 (rs1800872, rs1800871, rs1800896, rs1800890, and rs6676671) and IL10RA (rs3135932 and rs2229113) genes were analyzed. A lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes

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