| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6019974 | Journal of Neuroimmunology | 2016 | 8 Pages |
Abstract
Impaired immunity in NF1 patients. Nf +/- might induce the TGF-beta and IL-4 from CD4 + T cells. Decreased frequency of CD4 + T cells in NF1 patients are more activated (increased HLA-DR) and produce more IL-4 (Th2) and TGF-beta (immunosupressive). These cells might suppress the frequency of monocytes (CD14 +/CD16 +) expressing inflammatory cytokines TNF-alpha and IL-1beta. The CD86 (B7-2) expressing monocytes might interact with CTLA-4 and induces apoptosis from CD4 + T cells.154
Keywords
IL-8IL-10IL-1βNF1infAPCIL-17MCP-1PBMCsMPNSTGTPIP-10IL-6TGF-βMAP-KinaseMAPKallophycocyanininterferonInterleukin-8Interleukin-10interleukin-17interleukin-6Interleukin-1 betatransforming growth factor-betaMalignant peripheral nerve sheath tumortumor necrosis factor-alphaCarcinogenesisperipheral blood mononuclear cellsCytokinesTNF-αphycoerythrinLymphocytesMonocytesneurofibromatosis type 1Plexiform neurofibromaPNFmonocyte chemoattractant protein-1Guanosine triphosphate
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Authors
Karen C.L. Torres, Giselle Lima, Ana C. Simões e Silva, Isabela Lubambo, Luiz O. Rodrigues, Luiza Rodrigues, Kátia D. Silveira, Ãrica L.M. Vieira, Marco A. Romano-Silva, Débora M. Miranda,