| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6020020 | Journal of Neuroimmunology | 2016 | 7 Pages |
Abstract
In conclusion, transition metals activate microglia similar to MoDCs. In near-physiological concentrations Zn and Cu are the most effective mediators of innate immune activation. A clear synergism between innate responses to Zn/Cu and LPS was observed, shedding new light on the possible relation between oral metal exposure and neurotoxicity.
Keywords
NiCl2FCSTLRTHP-1GM-CSFRPMICoCl2MoDCgranulocyte–macrophage colony stimulating factorZnCl2CuSO4HgCl2Cobalt (II) chlorideInnate immune activationFeCl3Iron (III) chlorideDMEMLPSDulbecco's modified Eagles' mediumFACSPBS3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDMSOMTTEDTAethylene-diamine-tetraacetic acidinterleukinELISAEnzyme-linked immunosorbent assaytoll like receptorcluster of differentiationCNSdimethylsulphoxidefoetal calf serumdendritic cell(s)Monocyte-derived dendritic cellsNeurotoxicitycentral nervous systemlipopolysaccharideRoswell Park Memorial InstituteCSFCerebrospinal fluidPhosphate-buffered salineMultiple sclerosisMicrogliaMolecular weightoptical density
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Authors
Dessy Rachmawati, Laura A.N. Peferoen, Daphne Y.S. Vogel, Inás W.A. Alsalem, Sandra Amor, Hetty J. Bontkes, B. Mary E. von Blomberg, Rik J. Scheper, Ingrid M.W. van Hoogstraten,