Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020113 | Journal of Neuroimmunology | 2015 | 6 Pages |
Abstract
The present study compared lymphocyte and T memory subsets in currently untreated patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to glucocorticosteroid (GS) and intravenous immunoglobulin (IVIG) treated patients. Peripheral blood from 48 CIDP patients (21 untreated who were either treatment naïve or without treatment during the last 3Â months, 17 IVIG and 10 GS treatment) and from 12 age-matched controls was evaluated using flow cytometric analysis. Our data demonstrate that long-term GS treatment is associated with reduced frequencies of total CD4Â + T cells, CD4Â + memory subsets and NK cells while long-term IVIG treatment is associated with alterations of the CD8Â + memory compartment. Reduction of CD4Â + naïve T cell counts may explain the observation that GS treatment induces prolonged clinical remission compared to IVIG treatment.
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Authors
Juliane Klehmet, Max Staudt, Lena Ulm, Nadine Unterwalder, Andreas Meisel, Christian Meisel,