Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020243 | Journal of Neuroimmunology | 2015 | 6 Pages |
Abstract
Obesity is a possible risk factor of multiple sclerosis (MS), but the association between obesity and MS disease activity has not been explored. In a cohort of 86 MS patients, 80% of overweight or obese patients (BMI â¥Â 25 kg/m2) had MRI activity compared to 48% of the normal-weight patients (BMI < 25 kg/m2) (p = 0.001) during interferon-beta treatment. NEDA-status (no evidence of disease activity) was defined as a composite that consisted of absence of any relapses, sustained disability-progression and MRI-activity. Among normal-weight patients 26% obtained NEDA-status compared to only 13% of patients with BMI > 25 (p = 0.05). This may indicate that BMI affects interferon-beta treatment response.
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Authors
Silje Stokke Kvistad, Kjell-Morten Myhr, Trygve Holmøy, JÅ«ratÄ Å altytÄ Benth, Stig Wergeland, Antonie G. Beiske, Kristian S. Bjerve, Harald Hovdal, Finn LilleÃ¥s, Rune Midgard, Tom Pedersen, Søren J. Bakke, Annika E. Michelsen, PÃ¥l Aukrust,