Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020272 | Journal of Neuroimmunology | 2015 | 7 Pages |
Abstract
Subanalysis of a pilot study (NCT01085318) assessed correlations between serum ferritin and imaging assessments in relapsing-remitting multiple sclerosis patients (n = 23) receiving 44 μg interferon beta-1a subcutaneously three times weekly. At baseline, 12, and 24 weeks, mean ferritin was 75, 127 (p < 0.001 vs baseline), and 101 (p = 0.020 vs baseline) ng/mL. No relationship between ferritin and susceptibility-weighted imaging (SWI)-filtered phase of subcortical deep gray matter was found. Increasing ferritin correlated with decreasing lesion numbers on both fluid attenuated inversion recovery and SWI phase at 12 weeks (r = â 0.62; p = 0.003; n = 21), and with decreasing gadolinium-enhancing lesion volume at 24 weeks (r = â 0.71; p = 0.050; n = 8).
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Immunology
Authors
Michael G. Dwyer, Robert Zivadinov, Silva Markovic-Plese, Niels Bergsland, Mari Heininen-Brown, Ellen Carl, Cheryl Kennedy, Bianca Weinstock-Guttman, Brooke Hayward, Fernando Dangond,