Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020314 | Journal of Neuroimmunology | 2015 | 9 Pages |
Abstract
Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90 min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.
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Authors
Gino Nardocci, Aldo Martin, Sebastián Abarzúa, Jorge RodrÃguez, Felipe Simon, Edison P. Reyes, Claudio Acuña-Castillo, Cristina Navarro, Paula P. Cortes, Ricardo Fernández,