Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020330 | Journal of Neuroimmunology | 2015 | 11 Pages |
Abstract
Theiler's murine encephalomyelitis virus (TMEV) can induce demyelination or myocarditis in susceptible mouse strains. A deficiency of NKT cells exacerbated TMEV-induced demyelinating disease (TMEV-IDD) in SJL/J and BALB/c mice. In C57BL/6 background, however, NKT-cell-deficient Jα18 KO mice remained as resistant to TMEV-IDD as wild-type mice. Echocardiography and histology showed that Jα18 KO mice developed more severe myocarditis (greater T cell infiltration and fibrosis) than wild-type mice, suggesting a protective role of NKT cells in myocarditis in C57BL/6 mice. Jα18 KO mice had higher cardiac viral RNA and anti-viral antibody titers, but had lower lymphoproliferation and IL-4 and IL-10 production.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Eiichiro Kawai, Fumitaka Sato, Seiichi Omura, Nicholas E. Martinez, Pratap C. Reddy, Masaru Taniguchi, Ikuo Tsunoda,