Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020362 | Journal of Neuroimmunology | 2015 | 11 Pages |
Abstract
Compared to NPT, basal DAT aAbs titers were higher within most severe patients (then assigned to PT), specifically if carrying a DAT 10/10 genotype. DAT aAbs levels of NPT group resulted highly correlated with distinct subscales of Conners' Parent/Teacher Scales (Rs > 0.34), especially within DAT 10/10 genotype (Rs > 0.53). While T1 titers were elevated over T0 baseline for NPT children, such an increase was not observed in PT patients carrying at least one 9-repeat allele, who also showed behavioral response to subchronic MPH. After 12-24 months of MPH exposure, DAT aAbs titers in PT subjects were comparable to those of healthy controls, while titers remained significantly elevated in NPT patients. Data warrant further research on serum DAT aAbs, which could be used to confirm ADHD diagnosis and/or to monitor therapeutic efficacy of MPH.
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Authors
Grazia Giana, Emilia Romano, Maria Cristina Porfirio, Roberto D'Ambrosio, Silvia Giovinazzo, Miriam Troianiello, Eleonora Barlocci, Domenica Travaglini, Oleg Granstrem, Esterina Pascale, Luigi Tarani, Paolo Curatolo, Giovanni Laviola, Walter Adriani,