Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020398 | Journal of Neuroimmunology | 2014 | 8 Pages |
â¢Boosting of WSN-WT primed mice with WSN-Aβ1-10 inhibits anti-Aβ antibody responses.â¢Boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral antibody responses.â¢Boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral T cell responses.â¢Inhibition is associated with expression of Aβ1-10 within the context of an influenza virus.
Novel dual vaccine, WSN-Aβ1-10, based on the recombinant influenza virus, expressing immunodominant B-cell epitope of β-amyloid, simultaneously induced therapeutically potent anti-Aβ and anti-influenza antibodies. In this study we showed that boosting of WSN-WT primed mice with WSN-Aβ1-10 enhances anti-viral, but fails to induce anti-Aβ antibody responses. This inhibition is associated with expression of Aβ1-10 within the context of an inactivated influenza virus vaccine.These results demonstrate that the use of an inactivated influenza virus as a carrier for AD vaccine may not be applicable due to the possible inhibition of anti-Aβ antibody response in individuals previously vaccinated or infected with influenza.