Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020668 | Journal of Neuroimmunology | 2012 | 8 Pages |
Abstract
Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.
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Authors
B. Godoy, P. Murgas, J. Tichauer, R. Von Bernhardi,