Neonatal stress modulates sickness behavior: Role for proinflammatory cytokines

Neonatal stress increased the duration and augmented symptoms of sickness behavior induced by influenza virus infection or endotoxin challenge in mice. Since proinflammatory cytokines were implicated in sickness behavior, the present study sought to determine the effect of neonatal stress on cytokines-induced sickness behavior and on proinflammatory cytokine secretion. Data indicate that separation of mouse pups from the dams at an early age (maternal separation, MSP) increased the duration and augmented some of the symptoms of sickness behavior induced by proinflammatory cytokines. In addition, MSP partially suppressed cytokine and corticosterone secretion in response to endotoxin administration. These data may suggest that MSP increased sensitivity to the effects of proinflammatory cytokines on sickness behavior following an immune challenge.

► Maternal separation increased duration of sickness behavior induced by IL-1β or TNFα. ► Maternal separation augmented symptoms of sickness behavior induced by IL-1β or TNFα. ► Maternal separation reduced cytokine and corticosterone response to endotoxin.