Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020791 | Journal of Neuroimmunology | 2012 | 6 Pages |
Abstract
We investigated whether three relevant polymorphisms (C-1562T, microsatellite â 90(CA)14-24, and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 “C L Q” haplotype was associated with higher plasma MMP-9 concentrations in migraine patients.
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Authors
Alisson Martins-Oliveira, Flavia M. Gonçalves, Jose G. Speciali, Vanessa Fontana, Tatiane C. Izidoro-Toledo, Vanessa A. Belo, Fabiola Dach, Jose E. Tanus-Santos,