Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020801 | Journal of Neuroimmunology | 2013 | 10 Pages |
Abstract
ObjectiveAssess whether CD70Â + B cells contribute to EAE.Materials and methodsMOG-specific TCR transgenic mice (2D2) were crossed with mice with constitutive CD70 expression on B cells. The development of EAE and the phenotype of B-T lymphocytes were studied in 2D2xCD70 animals.ResultsSpontaneous EAE developed in 20% of 2D2xCD70 and 3% of 2D2 mice. EAE was also more severe in 2D2xCD70 versus 2D2 animals upon MOG immunization. The susceptibility of 2D2xCD70 to EAE was associated with fewer FoxP3Â + T cells.ConclusionsExpression of CD70 by B cells aggravates EAE possibly by reducing the number of regulatory T cells.
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Authors
G. FrancoSalinas, T. Cantaert, M.A. Nolte, P.P. Tak, R.A.W. van Lier, D.L. Baeten,