Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis

We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 × 10− 9) and allele frequency (Pa = 6.08 × 10− 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92).A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 × 10− 8) and allele frequency (Pa = 2.82 × 10− 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.