Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020819 | Journal of Neuroimmunology | 2013 | 5 Pages |
Abstract
While cytokine levels are normal, levels of ceramide genes were modulated both after fetal and perinatal asphyxia in the adult prefrontal cortex. Moreover, the combination of two subsequent asphyctic insults provides long-lasting neuroprotection in the prefrontal cortex probably by maintaining normal apoptosis and promoting cell proliferation. Better understanding of the effects of asphyxia on ceramide metabolism will help to understand the changes leading to brain tolerance and will open opportunities for the development of new neuroprotective therapies.
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Authors
Evi Vlassaks, Antonio W.D. Gavilanes, Johan S.H. Vles, Sarah Deville, Boris W. Kramer, Eveline Strackx, Pilar Martinez-Martinez,