Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020825 | Journal of Neuroimmunology | 2012 | 8 Pages |
Abstract
We found that rejuvenation of the recipient immunity by inoculation of young CD4+ T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4+ T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy.
Keywords
CAPSSAMP1TGFBI2-MEAIEDIL-1R2IL-7HSCsKGFTregsSGCsIL-1RAIL-1R1NGFmAbIL-1Concanavalin AAHLCD4+CD25+Foxp3+ regulatory T cellsCD4+ T cellH&EMonoclonal antibodyAge-related hearing lossThymus involutioninterleukin 1Interleukin 7Con Aautoimmune inner ear diseaseRegulatory T cellhematopoietic stem cellsspiral ganglion cellsCryopyrin-associated periodic syndromesKeratinocyte growth factornerve growth factormajor histocompatibility complexMHCHematoxylin and Eosin
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Authors
Hiroshi Iwai, Muneo Inaba,