Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6020889 | Journal of Neuroimmunology | 2011 | 6 Pages |
Abstract
Cladribine (2-chloro-2â²-deoxyadenosine) is a purine nucleoside analogue (PNA) which causes targeted and sustained reduction of peripheral lymphocyte counts. Cladribine tablets produced significant treatment benefit for patients with relapsing-remitting multiple sclerosis in the phase 3 CLARITY study. In addition to the well-characterised cell-specific phosphorylation of PNAs responsible for lymphocyte reduction, the mode of action of cladribine may encompass distinct activities contributing to its overall effects on the immune system. Here we demonstrate that clinically relevant concentrations of cladribine also inhibit cytokine secretion by human peripheral blood T cells in vitro through mechanisms independent of the induction of lymphocyte death.
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Authors
Bruno Laugel, Frédéric Borlat, Laurent Galibert, Alain Vicari, Robert Weissert, Yolande Chvatchko, Denis Bruniquel,