Association of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease

Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and −511C > T and − 31T > C (IL-1β) polymorphisms. Our findings revealed that − 511C/− 31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p = 0.005), whereas − 511C/− 31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p = 0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.