Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021067 | Journal of Neuroimmunology | 2011 | 8 Pages |
Abstract
Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N = 30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf + GI, N = 19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N = 28) and normal (N = 26) controls. This included a 4-5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf + GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf + GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes.
Keywords
TGF-ββ-LgIBDCRSTLRPBMCsIVIgCVIDCCL2FPIESSPADCNVFood proteinTNFTLRsα-Laβ-LactoglobulinFood allergyallergic conjunctivitisAutism spectrum disorderAutism Spectrum Disorders (ASD)standard deviationinterleukinIntravenous immunoglobulinInflammatory bowel diseasetransforming growth factor-βcopy number variationToll-like receptorPeripheral bloodCNSGastrointestinalROMrecurrent otitis mediaChronic rhinosinusitisAllergic rhinitisperipheral blood mononuclear cellsCytokinescentral nervous systemtumor necrosis factorTranscript profilinggenome wide association studiesGWASMultiple sclerosisASDSingle nucleotide polymorphismSNPCommon variable immunodeficiency
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Authors
Harumi Jyonouchi, Lee Geng, Deanna L. Streck, Gokce A. Toruner,