Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021069 | Journal of Neuroimmunology | 2011 | 9 Pages |
Abstract
The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.
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Authors
Kathryn M. Brennan, Francesc Galban-Horcajo, Simon Rinaldi, Colin P. O'Leary, Carl S. Goodyear, Gabriela Kalna, Ariel Arthur, Christina Elliot, Sue Barnett, Christopher Linington, Jeffrey L. Bennett, Gregory P. Owens, Hugh J. Willison,