| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021095 | Journal of Neuroimmunology | 2011 | 8 Pages |
Abstract
The relationship between cancer-initiating cells and cancer-related inflammation is unclear. Exploring the interaction between glioma-initiating cells (GICs) and tumor-associated microglia/macrophages (TAM/Ms) may offer us an opportunity to further understand the inflammatory response in glioma and the cellular/molecular features of the GIC niche. Hereï¼we reported a positive correlation between the infiltration of TAM/Ms and the density of GICs. The capacity of GICs to recruit TAM/Ms was stronger than that of adhesive glioma cells (AGCs) in vitro. In vivo experiments suggested that implantations formed by GICs had a higher level of TAM/M infiltration than those formed by AGCs. Our studies indicate a predominant role of GICs in microglia/macrophages tropism to glioma and a close positive correlation between the distribution of GICs and TAM/Ms. As an important part of cancer-related inflammation, TAM/Ms may participate in the architecture of the GIC niche.
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Authors
Liang Yi, Hualiang Xiao, Minhui Xu, Xianzong Ye, Jun Hu, Fei Li, Mei Li, Chunxia Luo, Shicang Yu, Xiuwu Bian, Hua Feng,