| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021158 | Journal of Neuroimmunology | 2011 | 9 Pages |
Abstract
The present study examined the bactericidal effects of orexin B (ORXB) and vasoactive intestinal peptide (VIP) alone or combined with cationic antimicrobial peptides, such as LL-37, on Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans and Staphylococcus aureus. The bactericidal effect of ORXB or VIP alone was detected in low NaCl concentration, but attenuated in physiological NaCl concentration (150Â mM). However, such attenuated bactericidal activities of ORXB and VIP in 150Â mM NaCl were regained by adding LL-37. Therefore, our results indicate that VIP and ORXB appear to mediate bactericidal effects in concert with LL-37 in the physiological context of mucosal tissue.
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Authors
Kouji Ohta, Mikihiko Kajiya, Tongbo Zhu, Hiromi Nishi, Hani Mawardi, Jane Shin, Leena Elbadawi, Nobuyuki Kamata, Hitoshi Komatsuzawa, Toshihisa Kawai,