| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021171 | Journal of Neuroimmunology | 2011 | 8 Pages |
Abstract
We investigated the optimum doses of phenytoin for treatment of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE). Oral and intraperitoneal administrations of 0.25 to 1.0Â mg per mouse (12.5-50Â mg/kg) 3 times a week improved the clinical course. Intraperitoneal injections of 1.0Â mg phenytoin were the most effective, as a significant reduction in EAE severity was seen after only 2 administrations with that protocol. Treatment efficacy was associated with amelioration of cellular infiltrates in the CNS, and an increase in CD4+Foxp3+ and CD4+CD25+CD127â regulatory T cells as well as CD8+ suppressor/cytotoxic T cells in blood.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Naomi Hashiba, Shigemi Nagayama, Shin-ich Araya, Hiroyuki Inada, Yoshifumi Sonobe, Akio Suzumura, Makoto Matsui,