| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 606153 | Journal of Colloid and Interface Science | 2016 | 10 Pages |
•Dual responsive nanovalve was introduced on hollow mesoporous silica nanoparticles.•Rhodamine 6G can be controlled release by redox and pH-stimulation.•Drug size selectivity delivery was realized by regulating the length of the stalks.•Designed nanovalve is compatible with larger Cargo molecule.
A pH and redox dual-responsive nanovalve with a long stalk was introduced on the surface of hollow mesoporous silica nanoparticles (HMSs-S1) to achieve cargo size selectivity delivery. The responsive nanovalve was designed by constructing of a stalk/β-cyclodextrins (CDs) supramolecular complex, which is based on an acid-labile acetal group and the host–guest interactions between β-cyclodextrins and ferrocenyl moiety (Fc). With stimulation by different pH and H2O2, Rhodamine 6G showed well-responsive behavior. On account of the long stalks of nanovalve, doxorubicin hydrochloride and 5-fluorouracil with different sized cargos are encapsulated in HMSs-S1 to test its behavior of cargo size-selective delivery. Moreover the HMSs-S2 with a short stalk based on β-CDs/Fc inclusion complex is synthesized to load small sized 5-FU drug as contrast experiment. Compared with HMSs-S2, HMSs-S1 is compatible with larger drug molecules such as Rhodamine 6G (R6G) and doxorubicin hydrochloride (DOX), while small sized 5-fluorouracil (5-FU) is unable to be sealed by the nanovalve. Dual responsiveness and drug size selectivity make mechanized HMSs possess potential applications in drug delivery system.
Graphical abstractpH and redox dual-responsive nanovalve with long stalk was introduced on the surface of hollow mesoporous silica nanoparticles to encapsulate larger drug molecule such as rhodamine 6G and doxorubicin hydrochloride, while small sized 5-fluorouracil unable to be sealed by the nanovalve. Dual responsiveness and drug size selectivity possess potential applications in drug delivery system.Figure optionsDownload full-size imageDownload high-quality image (129 K)Download as PowerPoint slide
