| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 607493 | Journal of Colloid and Interface Science | 2014 | 8 Pages |
•5-Allylbarbituric acid was utilized as precursor to prepare N-halamine nanoparticles.•Nanoparticles showed enhanced biocidal activity compared with their bulk counterparts.•Biocidal properties can be tailored by changing the particle size.
N-halamine-based antibacterial polystyrene nanoparticles with different particle size ranged from 91.5 nm to 562.5 nm were facilely fabricated by surfactant-free emulsion polymerization with 5-allylbarbituric acid served as N-halamine precursor. Effect of experimental parameters such as monomer concentration, initiator concentration, and ionic strength on particle size was investigated systematically. N-halamine-based antibacterial polystyrene nanoparticles showed enhanced antibacterial activity against both Gram-positive species Staphylococcus aureus and Gram-negative species Pseudomonas aeruginosa compared with bulk powder N-halamine. Biocidal activity of N-halamine-based antibacterial polystyrene nanoparticles can be tailored effectively by tuning particle size. Stability and bactericidal activity of N-halamine-based antibacterial polystyrene nanoparticles was detected as a function of extending period.
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