Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6093205 | Gastroenterology | 2015 | 57 Pages |
Abstract
NETs form in the pancreata of mice during the development of AP, and NET levels are increased in plasma from patients with AP, compared with controls. NETs regulate organ inflammation and injury in mice with AP, and might be targeted to reduce pancreatic tissue damage and inflammation in patients.
Keywords
STAT3HMGB1MMP-9cf-DNACXCL2PBSMPOcell-free DNAPMAROSMacrophage-1 antigeninflammationinterleukinneutrophil extracellular trapNETintraperitonealIntravenousLeukocytesMatrix metalloproteinase-9macrophage inflammatory protein-2signal transducer and activator of transcription 3Phosphate-buffered salineMac-1myeloperoxidaseHistonesAcute pancreatitisChemokinesReactive oxygen species
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Authors
Mohammed Merza, Hannes Hartman, Milladur Rahman, Rundk Hwaiz, Enming Zhang, Erik Renström, Lingtao Luo, Matthias Mörgelin, Sara Regner, Henrik Thorlacius,