Self-assembled monolayers of silver nanoparticles firmly grafted on glass surfaces: Low Ag+ release for an efficient antibacterial activity

A two-step, easy synthetic strategy in solution has been optimized to prepare authentic monolayers of silver nanoparticles (NP) on MPTS-modified glass surfaces, that were investigated by AFM imaging and by quantitative silver determination techniques. NP in the monolayers remain firmly grafted (i.e. not released) when the surfaces are exposed to air, water or in the physiological conditions mimicked by phosphate saline buffer, as UV–Vis spectroscopy and AFM studies demonstrate. About 15% silver release as Ag+ ions has been found after 15 days when the surfaces are exposed to water. The released silver cations are responsible of an efficient local microbicidal activity against Escherichia coli and Staphylococcus aureus bacterial strains.

Graphical abstractA stable monolayer of silver nanoparticles is easily obtained on glass surfaces, capable of local antibacterial effect due to partial Ag → Ag+ oxidation with no NP release.Figure optionsDownload full-size imageDownload high-quality image (91 K)Download as PowerPoint slide