Emulsions-directed assembly of gold nanoparticles to molecularly-linked and size-controlled spherical aggregates

Aggregation of gold nanoparticles into soluble spherical assemblies using bi-functional ligands i.e., dithiols has recently been demonstrated but with limited control over the size of such assemblies. Herein, we report a new approach to further control the size of water dispersible spherical assemblies by confining gold nanoparticles in tiny oil droplets in water (oil-in-water emulsions) followed by their cross-linking with alkanedithiols. By controlling the size of the oil droplets and the concentration of nanoparticles, the size of spherical aggregates can be controlled from 20 to 400 nm. Cryo-TEM micrographs confirm the formation of covalently-linked soluble spherical nanoparticle assemblies within the oil emulsions in water. Such size-controlled nanoparticle assemblies may have several potential applications including those in gas sensors, controlled delivery, and optical coatings.

Graphical abstractSize-controlled spherical assemblies of gold nanoparticles are formed by confining them in oil-in-water emulsions of controlled sizes followed by their cross-linking with alkanedithiols.Figure optionsDownload full-size imageDownload high-quality image (76 K)Download as PowerPoint slideResearch highlights► Oil-in-water emulsions used to produce spherical gold nanoparticle assemblies. ► The amount of gold nanoparticles in oil droplets limit the size of their assemblies. ► Controlling the size-distribution of oil droplets controls the uniformity of nanoparticle assemblies.