Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
609537 | Journal of Colloid and Interface Science | 2010 | 8 Pages |
Amiodarone aqueous systems at concentrations C ⩽ 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (TK = 70.6 °C) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below TK as a function of temperature. The nature of aggregates below TK at different concentrations was determined. Micellization is an entropy-driven process which is probably caused by a strong dehydration of the amiodarone backbone on micellization. CMC, micelle aggregation number and TK given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work.
Graphical abstractFirst hydration shell of amiodarone.Figure optionsDownload full-size imageDownload high-quality image (58 K)Download as PowerPoint slide