Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6099569 | Journal of Crohn's and Colitis | 2013 | 9 Pages |
Abstract
Our findings suggest that IL-8 is elevated and TGFβ is reduced in distal colitis. Lower concentration of IFNγ, IL-4 and IL-17A were also noted. TNFα levels were unchanged. These findings suggest that the inflammatory response in UC may predominantly involve IL-8 mediated neutrophil infiltration and failure of TGFβ mediated tissue healing.
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Authors
Daniel S. Pearl, Krina Shah, Mark A. Whittaker, Harriet Nitch-Smith, James F. Brown, Janis K. Shute, Timothy M. Trebble,