| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6099737 | Journal of Crohn's and Colitis | 2013 | 9 Pages |
Abstract
The increase in PAI-1 in high-grade dysplasia and carcinoma suggests a functional role for PAI-1 in malignant transformation in colitis-associated cancer. PAI-1 could also prove a useful diagnostic marker to identify patients at risk for neoplasia and it may be a useful therapeutic target to treat colitis-associated cancer.
Keywords
IBDTNFuPARuPAPAI-1TLR4HIFNF-κBERKtPAIL-1LPSIL-6interleukin-6interleukin-1DysplasiaRONSColon cancerHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)tumor necrosis factornuclear factor kappa-Btissue plasminogen activatorlipopolysaccharidePlasminogen activator inhibitor-1Ulcerative colitisReactive oxygen and nitrogen speciesToll-like receptor 4Urokinase
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Authors
Earl Gillespie, Susan E. Leeman, Luisa A. Watts, Jennifer A. Coukos, Michael J. O'Brien, Sandra R. Cerda, Francis A. Farraye, Arthur F. Stucchi,