Upper gastrointestinal involvement in paediatric onset Crohn's disease: Prevalence and clinical implications

► We evaluated the upper gastrointestinal localization in paediatric Crohn's Disease (CD)patients. ► At least half of paediatric onset CD patients have an upper gastrointestinal localization. ► Patients with upper involvement present an earlier onset and a more severe disease. ► The final outcome does not differ , but patients with upper involvement require more aggressive therapy.