Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6100472 | Journal of Crohn's and Colitis | 2011 | 5 Pages |
Abstract
We present here two siblings with a history of recurrent oral and genital ulcers, neurological and gastrointestinal manifestations. The diagnosis of Behçet's disease in a context of familial aggregation was assumed. Facing repeated steroid-dependent flares and failure of maintenance therapies with colchicine and intolerance to pentoxifilline and disulone, adalimumab was started. Rapid response was observed in both patients, with clinical remission after induction therapy, which currently sustains under maintenance schedule. This case report suggests the effectiveness of adalimumab as first anti-TNFα in case of steroid-dependent/resistant gastrointestinal BD.
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Authors
Chiara De Cassan, Bénédicte De Vroey, Catherine Dussault, Eric Hachulla, Sebastien Buche, Jean-Frédéric Colombel,