Article ID Journal Published Year Pages File Type
6100565 Journal of Crohn's and Colitis 2012 4 Pages PDF
Abstract
Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
Authors
, , , , ,