| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 611453 | Journal of Colloid and Interface Science | 2008 | 13 Pages |
Abstract
In this paper, we study the uptake of amitriptyline in aqueous solutions by liposomes consisting of a neutral lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and a negatively charged lipid 1,2-dioleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (DOPG). The 50:50 DMPC:DOPG liposomes at 0.72 mg lipid/mL loading reduce the free drug concentration in serum by about 30-40% at physiologically relevant concentrations.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Colloid and Surface Chemistry
Authors
Brett Howell, Anuj Chauhan,