| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119526 | Journal of Clinical Virology | 2016 | 26 Pages |
Abstract
The antigenicity of the 3rd IS is suitable for HBsAg calibration in laboratory tests. In contrast to the 2nd IS, the 3rd IS is representative for a highly endemic region. Similar to the 2nd IS and different from native HBsAg, preS domains are depleted, protein subunits are partially cross-linked and the HBsAg particles are partially aggregated in the 3rd IS. The HBV subgenotype differences between the two IS may lead to variations in different quantitative assays.
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Authors
Pia L. Seiz, Christina Mohr, Dianna E. Wilkinson, John Ziebuhr, Christian G. Schüttler, Wolfram H. Gerlich, Dieter Glebe,