Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119658 | Journal of Clinical Virology | 2016 | 4 Pages |
Abstract
Given that hyperphosphorylation of pRb is associated with dysregulation of the cell cycle, S-phase induction, and increased cell proliferation, our findings support an important role of TSPyV-mediated pRb deactivation in the development of TS. The observation that the pRb tumor suppressor is inactivated by TSPyV sT but not MCPyV sT provides further insights into the distinct pathobiological mechanisms of MCC and TS.
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Authors
Julie H. Wu, Rebecca A. Simonette, Harrison P. Nguyen, Hung Q. Doan, Peter L. Rady, Stephen K. Tyring,