Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119744 | Journal of Clinical Virology | 2016 | 8 Pages |
Abstract
CMVpp65-specific IFNγ production with expansion of CD28-CD8+ T-cells suggests an efficient control of latent CMV regardless of immunosuppressive therapy or in vitro blockade of TNFα or IL-6 in CMV-seropositive arthritis patients. Increased IgG-anti-CMV antibody concentrations and increased proportions of intracellular IFNγ-producing CMVpp65-specific CD8+ T-cells in long-term cultures propose a possibly role of endogenous CMV reactivations boosting antibody levels and a higher possibly CMV-driven IFNγ-mediated inflammatory potential of CD8+ T-cells in arthritis patients.
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Authors
Giovanni Almanzar, Marc Schmalzing, Raimund Trippen, Kerstin Höfner, Benedikt WeiÃbrich, Eva Geissinger, Thomas Meyer, Johannes Liese, Hans-Peter Tony, Martina Prelog,