| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6119774 | Journal of Clinical Virology | 2015 | 6 Pages |
Abstract
TLR3 and IFNγ were found to play an important role in HEV disease pathogenesis. Patients capable of expressing high levels of TLR 3 and robust IFNγ response are able to limit the disease and recover uneventfully; while the patients with lower expression of TLR3 and IFNγ progress to ALF.
Keywords
HEVMODSAVHORF2PRRsALFSIRSPBMCsDCsODNoligodeoxynucleotidePAMPsCTLsTLRstoll like receptorWorld Health Organizationperipheral blood mononuclear cellsDendritic cellsSystemic inflammatory response syndromeCytokineCytotoxic T lymphocytesToll like receptorsAcute liver failureacute viral hepatitisHepatitis E viruspathogen associated molecular patternsWHOpattern-recognition receptors
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Authors
Manasi Majumdar, R.K. Ratho, Yogesh Chawla, Mini P. Singh,