Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6119785 | Journal of Clinical Virology | 2015 | 6 Pages |
Abstract
Specific combinations of nucleotide analogues significantly reduce the ligand-protein interaction energies of the ebolavirus polymerase for natural nucleotides. Any nucleotide analogue on its own did not reduce ligand-protein interaction energies. This prediction encourages specific drug testing efforts and guides future strategies to inhibit ebolavirus replication.
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Authors
Formijn J. van Hemert, Hans L. Zaaijer, Ben Berkhout,