Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6120367 | Journal of Clinical Virology | 2015 | 6 Pages |
Abstract
Anti-poliovirus antibody A12 effectively neutralizes a range of wild and VDPV strains and protectstransgenic mice susceptible to poliovirus against lethal challenge upon pre- and post-exposure administration. This suggests that the antibodies could be used in combination with drugs and/or vaccine to improve their efficacy and prevent emergence of resistant variants, and provides a justification for initiating their clinical evaluation.
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Authors
Diana Kouiavskaia, Zhaochun Chen, Eugenia Dragunsky, Olga Mirochnitchenko, Robert Purcell, Konstantin Chumakov,