Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6129062 | Clinical Microbiology and Infection | 2016 | 4 Pages |
Abstract
To evaluate the human herpes virus 6 (HHV-6) -specific immune response in individuals with chromosomally integrated HHV-6 (ciHHV-6), we measured HHV-6-antigen-specific cytokine responses (interferon-γ, interleukin-2, tumour necrosis factor-α) in T cells by flow cytometry in 12 and 16 individuals with and without ciHHV-6, respectively. All individuals with ciHHV-6 showed HHV-6-specific T cells with higher frequencies of HHV-6-specific CD8+ cells (0.03-14.93, median 2.15% of CD8+ cells) compared with non-ciHHV-6 (0.0-10.67, median 0.36%, p 0.026). The observed increased HHV-6-specific functionally active responses in individuals with ciHHV-6 clearly disprove speculations on immune tolerance in ciHHV-6 and indicate clinical and immunological implications of ciHHV-6.
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Authors
V. Strenger, S. Kayser, K.-E. Witte, D. Lassner, W. Schwinger, G. Jahn, C. Urban, T. Feuchtinger,