Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6129207 | Clinical Microbiology and Infection | 2015 | 15 Pages |
Abstract
We identified 2912 Shigella isolates from diarrhoeal patients in China during 2003-2013. The most common species was Shigella flexneri (55.3%), followed by Shigella sonnei (44.1%); however, S. sonnei is becoming increasingly prevalent. Among the S. flexneri isolates, serotypes 2a and X variant (-:7,8, E1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. Overall, S. sonnei, S. flexneri 2a and S. flexneri X variant (-:7,8, E1037) accounted for 76.1% of all Shigella isolates, and their prevalence increased from 54.0% during 2003-2004 to 84.1% during 2011-2013. A change was observed in the serotype distribution of Shigella in China during this period, and we propose an ideal strategy to inform the development of a broadly effective Shigella vaccine candidate.
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Authors
S. Qiu, X. Xu, C. Yang, J. Wang, B. Liang, P. Li, H. Li, S. Yi, H. Liu, X. Cui, Z. Wu, J. Xie, L. Jia, L. Wang, R. Hao, H. Jin, Y. Wang, Y. Sun, H. Song,